Two of the most influential and pioneering figures in the world of anti-aging and longevity are Dr David Sinclair and Peter Diamandis. 

Both of these figures have led the charge, helping bring anti-aging products like NMN into the mainstream. 

Sinclair and Diamandis both take a scientific approach to their work, with Sinclair conducting research out of his own lab at Harvard University. 

In this guide, we explore the influence these two figures have had. We examine their own anti-aging regimes and explore more of the science behind their theories, but first, let’s take a look at longevity practices and, in particular, the supplement called NMN.

 

Important Information About NMN And Longevity Practices

 

If you’re new to the concept of longevity practices, it refers to a set of behaviors, habits and lifestyle choices that are aimed at extending your life span. 

These practices can range from taking supplements to eating certain types of foods. For example, recent studies have shown that a Mediterranean diet, rich in fruits, vegetables and lean protein, can help lead to a longer life. 

 

 

Other practices such as regular exercise, getting enough sleep, and focusing on reducing stress in your life can all help you live a healthier, longer life.

However, in recent years, more research has been conducted on the impact of taking supplements to help boost longevity. Particular focus has been paid to a molecule called nicotinamide mononucleotide, often abbreviated to NMN. 

This little molecule occurs naturally in the cells of our bodies. Its purpose is to repair any damaged DNA but it also helps with our metabolism, which slows as we age. The theory behind this then is to give our bodies a boost of NMN. This, in turn, helps us produce other molecules, like NAD+, which can help combat the aging process. 

Let’s take a look at some of the potential benefits of taking NMN. 

 

What Are The Benefits Of Taking NMN?

 

As both David Sinclair and Peter Diamandis have said, there are potential benefits to taking supplements like NMN. There is also a growing body of scientific research building behind these claims too. For example:

• Anti-aging - one of the primary reasons people take NMN is to help combat aging. Early studies, such as by Mendelsohn AR, et al (2014) have found that NMN supplements had the ability to restore muscle in older mice. Human studies into this are ongoing. 
• Improved Brain Function - another potential benefit of taking NMN is the impact it has on our mental functioning. A study by Wang X, et al (2016), which was published in Brain Res, found that NMN helped slow the mental decline of a mental disease akin to Alzheimer’s in mice. Again, research conducted on humans remains ongoing. 
• Help With Diabetes - further studies conducted on mice have also found that NMN could play a role in regulating insulin and glucose in the body, which can have a positive impact on diabetes sufferers.

One question you may be asking is whether NMN is safe given that many of the studies so far have been conducted on mice. Let’s take a look. 

 

Is NMN Safe?

 

As it stands, NMN is regarded as a safe supplement to take. There are no widely reported side effects other than mild stomach upset and nausea which could be linked to taking the wrong dosages. 

While studies are still ongoing on humans, it’s advised that pregnant women and those who are breastfeeding avoid taking NMN. 

It’s always best to speak with a medical professional if you’re unsure. You could also try starting with a low dosage and seeing how your body responds. 

 

Who Is Dr David Sinclair?

 

If you’ve done a bit of research into NMN, you may well have come across Dr David Sinclair.

Dr Sinclair is a world leader in longevity and devotes his time and effort to lifespan research. He does this out of his lab at the prestigious Harvard Medical School, where he’s been based since 1999. 

His research has sought to identify the reasons why the body ages and different methods to slow down that process.

Much of that research has focused on aging on a cellular level, looking at the impact of the likes of NAD+ and NMN. In fact, it was the Sinclair lab that was the first to identify NAD+ as playing a key role in aging. 

Dr Sinclair’s research has also identified a molecule called resveratrol as playing a key role. This is an antioxidant that occurs naturally. You can find it in berries, red wine and peanuts. According to some studies, it can help boost mood, increase heart strength and improve gut function.

 

 

What Supplements Does David Sinclair Take?

 

We mentioned a supplement called resveratrol above. This is in fact something that Dr Sinclair has stated that he takes each day. According to Fortune.com, Sinclair has been taking it each morning for the past 15 years. 

Sinclair said that each morning he likes to take the molecule in the form of a supplement and usually mixes it with yoghurt. 

Along with resveratrol, Sinclair has said that he also takes a gram of NMN, again mixing it in with yoghurt. This suggests he takes it in powder form and mixes it in. 

The idea behind this supplement mix is to boost NAD+ levels, which Sinclair’s research suggests plays an important role in fighting aging. 

Sinclair has written about his supplement regime extensively and the best account you can find in his book, "Lifespan: Why We Age - And Why We Don't Have To."

It’s important to stick to guidelines when it comes to taking any supplement. Sometimes people think taking more will help them, when in fact they take more than what their body can handle.  

 

The Influence Of Peter Diamandis

 

Peter H Diamandis is regarded as a leader in the world of business. He formed the XPRIZE Foundation and also the Singularity University, which helps advise world leaders on new technologies. 

He’s a serial and successful entrepreneur and bestselling author and speaker at events and conferences all around the world. He also has a keen interest in longevity and in particular NMN. 

Both Sinclar and Diamandis have spoken together about their research into NMN. In August 2023 in an interview on Diamandis’s YouTube channel, Sinclair said that NMN had the potential not just to help with aging but to help with general health too. 

 

What Supplements Does Peter Diamandis Take?

 

Like Sinclair, Diamandis is said to go through a strict health regime, with supplements playing a part. 

He shares openly on his website his medication and his supplement regime. A part of that is creatine, which he takes with his morning workouts. This helps boost muscle strength and endurance as well as help with mobility and physical function. 

He also takes Lion’s Mane, which is a mushroom which helps protect brain cells. Antioxidant-based supplements also feature heavily. Diamandis says he regularly takes Selenomethionine to boost his immune system, as well as reduce the chance of developing chronic illnesses. It’s also been linked to longevity. Alpha lipoic acid is another antioxidant supplement Diamandis says he takes, and this too has also been linked with anti-aging. 

Diamandis also takes 1 gram of NMN a day, just like Sinclair. He also combines this with a product named Nuchido TIME+. This helps with the processing of NMN and the production of NAD+. 

However, as with any supplement, and as advised by Diamandis himself, you should check it won’t interfere with any other medications you may take, as well as exacerbate any medical conditions you may have. The best thing to do is check with your doctor if you’re unsure.

 

 

What Can We Learn From Sinclair And Diamandis About Longevity Practices?

 

One of the biggest things we can learn from both Sinclair and Diamandis is that a routine is key. Combating aging also relies on a lifestyle change. Taking supplements alone isn’t enough. You need to exercise more and eat different foods. 

As Sinclair told GQ in an interview, after changing his diet he found a major improvement in his brain function and memory. “I was unable to remember phone numbers and key codes easily, and now it’s simple,” he said. 

 

Learn More About NMN And Try It Today

 

Anti-aging supplements are an area that’s growing in both interest and demand. If you’d like to learn more about some of the products available, why not check out the JOOSH store?

You can find a range of different NMN supplements, from capsules to powders. They come in a variety of strengths, too, meaning you can get what you need for your own regime. 

If you’d like some help and support or have a question, you can also write to us here. We’ll get back to you as soon as we can.

 

Key Takeaways

 

• Dr David Sinclair is a world leader in anti-aging research. Out of his lab at Harvard Medical School, he identified NAD+ as playing a key role in the aging process.
• Sinclair and entrepreneur Peter Diamandis have both stated that they take supplements each day. They take 1 gram of NMN, as well as others like resveratrol. 
• It’s important to remember that supplements alone won’t work. A complete lifestyle change is needed to combat the effects of aging.